GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs4372836 | 1 | rs7598876 | chr2:28974466 | TRMT61B | chr2:29072690-29093175:- | -0.5 | -4.16 | 6.98E-5 | Body mass index |
| THYM | cis | rs757978 | 1 | rs7601738 | chr2:242375813 | SEPT2 | chr2:242254723-242293439:+ | -0.43 | -5.91 | 5.25E-8 | Chronic lymphocytic leukemia |
| THYM | cis | rs9309473 | 1 | rs7604682 | chr2:73788026 | ALMS1P | chr2:73872046-73912692:+ | 0.57 | 4.64 | 1.09E-5 | Metabolite levels |
| THYM | cis | rs1930961 | 1 | rs760554 | chr22:25872592 | CRYBB2 | chr22:25615612-25627836:+ | 1.13 | 7.35 | 6.76E-11 | Bipolar disorder with mood-incongruent psychosis |
| THYM | cis | rs1930961 | 1 | rs760555 | chr22:25872837 | CRYBB2 | chr22:25615612-25627836:+ | 1.07 | 7.43 | 4.62E-11 | Bipolar disorder with mood-incongruent psychosis |
| THYM | cis | rs60843830 | 1 | rs7605824 | chr2:280819 | SH3YL1 | chr2:218138-264810:- | 0.33 | 4.79 | 6.07E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs9309473 | 1 | rs7607014 | chr2:73730174 | ALMS1P | chr2:73872046-73912692:+ | -0.56 | -4.47 | 2.18E-5 | Metabolite levels |
| THYM | cis | rs7608910 | 1 | rs7608697 | chr2:61204641 | C2orf74 | chr2:61372243-61391964:+ | 0.37 | 4.2 | 5.94E-5 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THYM | cis | rs7608910 | 1 | rs7608910 | chr2:61204856 | C2orf74 | chr2:61372243-61391964:+ | -0.37 | -4.23 | 5.43E-5 | Crohn's disease;Ulcerative colitis;Inflammatory bowel disease |
| THYM | cis | rs344081 | 1 | rs7609851 | chr3:156638503 | LEKR1 | chr3:156544076-156763918:+ | -0.72 | -4.3 | 4.1E-5 | Bone mineral density |
| THYM | cis | rs10935120 | 1 | rs7611611 | chr3:134307877 | ANAPC13 | chr3:134196547-134204865:- | 0.55 | 7.48 | 3.7E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs7611611 | chr3:134307877 | CEP63 | chr3:134204575-134293852:+ | 0.43 | 6.36 | 7.09E-9 | Height |
| THYM | cis | rs10935120 | 1 | rs7611828 | chr3:134250325 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 8.01 | 2.88E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs7611828 | chr3:134250325 | CEP63 | chr3:134204575-134293852:+ | 0.41 | 6.04 | 2.93E-8 | Height |
| THYM | cis | rs7615952 | 1 | rs7615952 | chr3:125649403 | LOC100125556 | chr3:125635444-125648865:+ | -0.7 | -5.85 | 6.81E-8 | Blood pressure (smoking interaction) |